Waters Ultra Performance Convergence Chromatography System Debuts in China

October 16, 2012 Shanghai – Waters ® at analytica China in Munich launches the latest technology Waters ACQUITY UPC 2 TM system, a new category for separation of scientific instruments. A supplement to the orthogonal separation technique is used to solve complex chromatographic problems, especially for handling samples of different polarities. 　　
This time, Waters will also introduce NuGenesis ® 8 based on LE (Laboratory Execution) technology, a comprehensive data management system that can effectively connect multiple analytical laboratory data systems from different organizations to their business information technology systems. And workflow solutions.
　　
Waters recently launched a new product line for research laboratories: analytical standards and reagents that for the first time combined more than 200 pre-formulated reference materials and reagents. The introduction of new products meets customers' needs for enhanced problem solving, efficiency, and data reliability. 　　
In addition, Waters added two new mass spectrometers to its popular Xevo ® mass spectrometer product line - the Xevo G2-S QTof and Xevo G2-S Tof mass spectrometers. This is Waters' first quadrupole quadrupole StepWaveTM ion optics patented technology is used in rod flight time mass spectrometer products. StepWave is a unique off-axis ion source technology that provides stability, reproducibility, and high sensitivity for mass spectrometry.


Waters Biochemical Exhibition Booth at Munich

　　 Waters is the first in the industry to introduce an ultra-high efficiency chromatography system

Waters ACQUITY UPC 2 System Debuts
With the advent of a new class of separation science instruments, the Waters ACQUITY UPC 2 System is proving to be a complementary, reliable chromatography that provides unique workflow, application and environmental impact benefits for liquid and gas chromatography platforms. platform. UCP 2 uses the principle of Ultra-High Efficiency Convergence Chromatography (UPC 2 ). Waters ACQUITY UPC 2 System is a supplement to orthogonal separation technology to solve complex chromatographic problems. It is especially suitable for processing samples with different polarities. Any laboratory using liquid chromatography or gas chromatography will benefit from the addition of converging chromatography in its analytical technology. 　　
“The ACQUITY UPC 2 always performed well when we responded to each challenge . We had also analyzed extremely difficult-to-separate mixtures of 18 compounds, including amines, vitamin isomers, steroids, and antibacterial agents—all at the same time. A mixture," said Barry Upton, director of strategic projects at Waters. “The results were surprising. We found that the peak widths were narrow, stable, and reproducible, and all exhibited a very low baseline noise in a gradient mode of operation. The overall design resulted in a lower system volume and smaller particle size. The column, which can use compressed CO2 and benefit from it, has never been realized before. I have used this technology in my work for more than 18 years, but I have never seen such a high level of performance with my own eyes. ” 　　
The main mobile phase of UPC 2 "Compressed Carbon Dioxide (CO2)" shows numerous significant advantages when compared to the liquid mobile phase or carrier gas used in liquid chromatography and gas chromatography. Compared to liquids used in HPLC, CO2, when used alone or in combination with a co-solvent, is a low-viscosity mobile phase that achieves higher diffusion rates and greater mass transfer capabilities. Compared with gas chromatography, CO2 alone is used as the mobile phase, allowing separation at much lower temperatures. 　　
Another advantage of the Waters ACQUITY UPC 2 System is the use of inexpensive and non-toxic compressed CO2 as the main mobile phase, which can replace expensive volatile solvents that are extremely expensive and costly to destroy.
　　 Liquid chromatography and gas chromatography of the compounds is not easy modification (including different polar molecules) are currently performed by conventional separation scientists. 　　
Utilizing industry-leading sub-2-micron particle technology column chemistry, the Waters ACQUITY UPC 2 System enables scientists to accurately change the mobile phase concentration, pressure and temperature. With this ability to finely adjust the resolution and selectivity of the instrument system, scientists can better control the retention of analytes to achieve structural analogs, isomers, and enantiomeric and diastereomeric The body mixture is separated, detected and quantified.
　　
　　 New analytical standards and reagents

Waters New Analytical Standards and Reagents and Column Booths

Waters has been working on the preparation of calibrators and reference materials for its own HPLC systems and HPLC/MS systems for many years. A new production line has been launched: analytical standards and reagents for use in this year. January LC and LC/MS produced by a dedicated agency in Golden, Colorado, USA. Through this organization, Waters is now able to provide its global customer base with more than 200 pre-packaged and pre-measured ready-to-use standards and reagents.
　　
“Through our investigation, we learned that 90% of scientists conducting LC or LC/MS analysis use standards and reagents on a daily basis. And scientists spend a lot of time using raw materials purchased from many suppliers to formulate their own use. Standards, buffers, and reagents,” said Mike Yelle, senior director of commercial operations at Waters Chemicals. “Until now, however, no single supplier has been able to offer a variety of designs specifically for LC and LC/MS systems. Certified ready-to-use standards and reagents. We want to be a supplier with this exclusive source."
　　
Today, scientists can get everything they need from Waters; from pre-formulated small molecule single-component standards to multi-component test mixtures to protein hydrolysates and polysaccharide standards. In the future, Waters will add new products to its product portfolio according to customer needs.

For Waters customers, ready-to-use analysis standards and reagents mean that they can track raw material records through a complete chain, first to achieve absolute traceability, so that the laboratory manager and review The staff can evaluate the quality of the chemical assay. Second, Waters' analytical standards and reagents represent precise formulation at all times, which can significantly reduce discrepancies between different analyses, different instruments, and different laboratories.
　　
The addition of analytical standards and reagents to Waters' product portfolio demonstrates that Waters is committed to providing comprehensive system solutions and maximizing the value of Waters technology.
　　
　 Leveraging Laboratory Execution Technology to Connect Scientific Research with Commercial Operations

Waters NuGenesis ® 8 Information Systems Booth
Waters ' NuGenesis ® 8 based on LE (Laboratory Execution) technology is a comprehensive data management and workflow solution that effectively connects multiple analytical laboratory data systems from different organizations to their business information technology systems.

“Perhaps the biggest IT challenge facing our customers is too many software products,” said Mary Ellen Goffredo, Senior Director of Marketing Systems, Waters Corporation. “Every analytical instrument has a software product for data generation and support Office applications for databases, spreadsheets, and documents—all of which are necessary to ensure that the lab is working effectively. Because of the large number of software applications, scientific institutions cannot efficiently collect, process, and integrate large amounts of laboratory data. NuGenesis 8 enables global scientific institutions to keep information flowing across different laboratories, countries, and continents, standardize the analysis process, and implement best practices. This means faster and easier compliance operations. Make more informed business decisions."
　　
The key to NuGenesis 8 is its newly developed LE technology, a documented workflow and workflow solution that guides laboratory analysts through standard methods of routine operation. Lab analysts can see electronic worksheets in the instrument workstations that guide them through the steps above to ensure that they can complete each step and confirm that all input values ​​meet the established standards. The information they generate is then collected and shared with QC institutions and business systems such as LIMS and ERP.
　　
In addition to featuring LE technology, NuGenesis 8 also has access to a comprehensive set of information management technologies including sample management systems. Using the NuGenesis Electronic Laboratory Notebook (ELN), laboratories can trace, assign, and manage samples, tests, and results. The user-centered design takes into account both the needs of laboratory managers seeking laboratory workload measurement standards, and the need for analysts to quickly overview the needs of ongoing tasks and ongoing testing. The result is an increase in the efficiency of the laboratory.
　　
　　 Apply StepWave Ion Optics to Two New Xevo Mass Spectrometers

Xevo G2-S QTof and Xevo G2-S Tof Mass Spectrometer Booth

Waters also demonstrated the addition of two Xper G2-S QTof and Xevo G2-S Tof mass spectrometers to the new Xevo ® family of mass spectrometers, the first Waters quadrupole flight in the world. TimeWaveTM ion optics patented technology is used in time mass spectrometer products. StepWave is a unique off-axis ion source technology that provides stability, reproducibility, and high sensitivity for mass spectrometry.
　　
"Mass spectrometry is the backbone of today's analytical laboratories. With mass spectrometry becoming the mainstream and major analytical technology, scientists have higher expectations of this technology. Waters is passing this analysis. At the two ends of the range, innovative technologies are introduced to respond, from R&D to daily analysis,” said Brian Smith, vice president of mass spectrometry operations at Waters. “With these innovations we are launching today, we are starting new scientific discoveries. And help the lab get more accurate results faster.”
　　
Waters StepWave ion optics technology maximizes instrument sensitivity while minimizing instrument routine maintenance. This technology transfers ions from the ion source with the highest efficiency, while at the same time it can effectively filter out unwanted neutral impurities. In this way, the MS signal is greatly enhanced; and because key parts of the instrument can be kept clean for long periods of time, the reproducibility of quantitative results can be improved and laboratory downtime caused by routine cleaning and maintenance can be shortened.
　　 StepWave takes the performance of the Xevo quadrupole time-of-flight mass spectrometer and time-of-flight instruments to a new level, providing superior UPLC ® compatible mass spectrometry resolution, matrix tolerance dynamic range, quantitative performance, and mass spectrometry accuracy at the same time And analysis speed; these performances were previously only available on benchtop Waters Xevo TQ-S (tandem quadrupole) mass spectrometers and Waters SYNAPT G2-S HDMS mass spectrometers.
　　
GlaxoSmithKline Pharmaceuticals is a company that has benefited from StepWave technology. "Microsampling - using dry blood spots (DBS) or using new technology to separate less than 50 microliters of plasma - is an area of ​​innovation currently being tackled by GlaxoSmithKline," GlaxoSmithKline Pharmaceuticals' Bioanalytical Sciences and Poisons Dr. Chet Bowen, a researcher in the metabolomics PTS DMPK department, said, “In some cases, we want to use 5-10 microliters of biological matrix, so we need to be able to use a very small amount of sample to achieve a lower level of pg/mL. Detection limit of the mass spectrometer detector; this is why we chose to use Waters Xevo TQ-S based on StepWave technology. By combining with the ACQUITY UHPLC system, it allows us to achieve a smaller matrix volume easily The lower limit of quantification. In addition, this combination of instruments helps to achieve low LLQ requirements, which in turn supports our research on inhalant and biopharmaceutical projects."
　　
Since its introduction in 2008, the Waters Xevo mass spectrometer has been known for its simplicity and versatile ion source architecture, allowing scientists to select the most suitable ion source for the current analysis among a wide range of alternative ion sources. All Xevo mass spectrometers also feature IntelliStartTM technology, which automatically performs mass spectral separation and calibration checks and monitors system performance during an analysis.
　　
So no matter where science is focused on: systems biology, biopharmaceutical characterization, metabolite analysis, forensic toxicology, food analysis, or environmental research, Xevo mass spectrometers enable scientists to make correct decisions quickly and with confidence.
　　
　　 About Waters Corporation
　　
For more than 50 years, Waters Corporation (NYSE:WAT) has made significant advancements in the areas of medical services, environmental management, food safety, and global water quality monitoring by providing practical, sustainable innovations that are relevant for laboratories. Institutions create business advantages.
　　
As a pioneer in a range of separation science, laboratory information management, mass spectrometry and thermal analysis technologies, Waters technology breakthroughs and laboratory solutions have created a lasting platform for customer success.
　　
In 2011, Waters Corporation had a revenue of 1.85 billion U.S. dollars. It will continue to lead customers around the world in exploring science and achieving outstanding achievements.